The Vallee Foundation is governed by the Board of Directors led by Peter Howley, President, Gordon Hammes, Vice President, Peter Campot, Treasurer, and Jesper Haeggström, Secretary. Day-to-day operations of the Vallee Foundation are managed by Alexa Mason, Executive Director.

Directors
- Past President, The Vallee FoundationPaul C Cabot Distinguished Professor of Medical Biophysics (Emeritus), Harvard Medical School
- Treasurer, The Vallee FoundationDirector of Construction, Wynn Everett
- Vice President, The Vallee FoundationProfessor of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, VVP 2006
- Director, The Vallee Foundation
- Director, The Vallee FoundationDirector of the Cardiovascular Program, Karolinska Institutet, Professor, Department of Biochemistry and Biophysics, Karolinska Institutet, VVP 2008
- President, The Vallee FoundationShattuck Professor of Pathological Anatomy &, Professor of Microbiology and Immunobiology, Harvard Medical School, VVP 2010
- Assistant Treasurer, The Vallee Foundation
- Director, The Vallee FoundationManaging Director, Grove Financial Services GmbH
- Director, The Vallee FoundationDr Lee's Professor of Chemistry, University of Oxford, President, Royal Society of Chemistry, VVP 2016
- Director, The Vallee FoundationGene Center Munich, LMU, VVP 2012
Directors Emeritus
- Vallee Foundation Director EmeritusEmeritus Professor of Biochemistry, VVP 1998
- Vallee Foundation Director EmeritusDistinguished Service Professor of Biochemistry Emeritus, Duke University, VVP 1999, VVP 2001
- Vallee Foundation Director Emeritus
Officers
- Executive Director, The Vallee Foundation
- Assistant Secretary, The Vallee FoundationDirector, Rackemann, Sawyer & Brewster