Single-cell genomics has revolutionized biology and medicine, and my lab pioneered single-cell RNA-sequencing by developing core technologies such as Smart-seq2 and Patch-seq. My lab has used these technologies to study gene regulation (including both transcriptional and post-transcriptional), exploring how transcriptional bursting kinetics are encoded in genomic regulatory regions, as well as allelic expression dynamics over time in cells. We are currently investigating how alternative splicing shapes functional diversity of neurons in the brain, and decoding alternative splicing regulation. This knowledge is crucial for understanding how variations in gene expression manifest and impact development of characteristics and ultimately genetic disease.

Rickard Sandberg is Professor of Molecular Genetics at Karolinska Institutet (KI). Prior to starting his lab at KI, Dr. Sandberg was a graduate student with Ingemar Ernberg at KI and a post-doctoral fellow with Christopher Burge at Massachusetts Institute for Technology. Dr. Sandberg has received awards including the Torsten Söderberg Academy Professorship in Medicine (2023), Göran Gustafsson prize in Molecular Biology (2018), Anders Jahre’s medical prize for young medical research (2014, Nordic prize), Åke Wiberg Prize (2009), and Sven and Ebba-Christina Hagbergs Prize (2012).

Rickard is an elected member of the Swedish academy of sciences (2024), EMBO (2019), and the Nobel Assembly at Karolinska Institutet (2019).
 

Sandberg Lab