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Boston, MA
Boston, MA 2014

Protein Homeostasis, Metabolism, and Cancer

Major advances in biomedical research are being made in understanding disease mechanisms from the point of view of the genome, the metabolome and the proteome.  The 2014 Vallee Symposium, held at the Mandarin Oriental Hotel, Boston, in August 2014, was organized by Peter Howley (VVP 2009), Wade Harper (VVP 2000), and Lew Cantley (VVP 2006).  It brought together 16 world-renowned scientists working in related areas to present their newest work.  The meeting was greatly complemented by 12 Boston area academic scientists working in these areas, as well as a number of other previous VVPs and Vallee Foundation Board members, who made sure the question period was as stimulating as the presentations.  The scientific program was further augmented by a group of twenty postdoctoral trainees from Boston and beyond, who presented their work in a lively poster session on the first afternoon.  

 With a particular focus on cancer, topics that were presented and discussed at the meeting include:

Autophagy and mitophagy

  • Ana Maria Cuervo (Albert Einstein College of Medicine)
  • Ivan Dikic (Goethe University School of Medicine)
  • Jennifer Lippincott-Schwartz (Eunice Kennedy Shriver National Institute of Child Health and Human Development)


Signaling through phosphorylation and ubiquitin

  • Nicholas Tonks (VVP) (Cold Spring Harbor)
  • Lewis C Cantley (VVP) (Weill Cornell Medical School - New York Presbytarian Hospital)
  • Sir Philip Cohen (VVP) (University of Dundee)
  • Brenda Shulman (St Jude Children's Research Hospital)


Protein homeostasis

  • Kylie Walters (Univ of Minnesota)
  • Ulrich Hartl (Max Planck Institute of Biochemistry)
  • Jeffery Kelly (The Scripps Research Institute)
  • Chris Claiborne (Takeda Pharmaceuticals International Co)


Metabolism, cancer and p53

  • Craig Thompson (Memorial Sloan Kettering Cancer Center)
  • David Sabbatini  (MIT)
  • Arnold Levine (VVP) (Institute for Advanced Study, Princeton)
  • Karen Vousden  (University of Glasgow)